ELISA LG anti-

Quantity :100µL Clone Number: Aliases:C kit ligand antibody; C-kit ligand antibody; Ckit ligand antibody; DCUA antibody; DFNA69 antibody; DKFZp686F2250 antibody; familial progressive hyperpigmentation 2 antibody; FPH2 antibody; FPHH antibody; KIT ligand antibody; Kitl antibody; KITLG antibody; KL 1 antibody; KL1 antibody; Mast cell growth factor antibody; MGF antibody; MGF stem cell factor antibody; SCF antibody; SCF_ antibody; SF antibody; SHEP7 antibody; sKITLG antibody; Soluble KIT ligand antibody; Steel factor antibody; steel, mouse, homolog of antibody; Stem cell factor antibody; Stem cell factor precursor antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P21583 Immunogen:Peptide sequence around aa.265~269(E-K-E-R-E) derived from SCF. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; WB:1:500-1:1000 Background:Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regµLation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regµLatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellµLar signaling molecµLes diacylglycerol and inositol-1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. Lu H.S., Clogston C.L., Wypych J. Arch. Biochem. Biophys. 298:150-158(1992) Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:KITLG Research Areas:Developmental biology;Immunology;Stem cells