ELISA FOXN4 anti-

Quantity :100µL Clone Number: Aliases:FOXN4Forkhead box protein N4 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96NZ1 Immunogen:SyntheQuantityd peptide derived from internal of FOXN4. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from mµLtipotent retinal progenitors while suppressing the alternative photoreceptor cell fates throµgh activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricµLar canal and is indirectly required for patterning the distal airway during lung development By similarity. Scherer S.E., Nature 440:346-351(2006). Danilova N., Brain Res. Dev. Brain Res. 153:115-119(2004). Ota T., Nat. Genet. 36:40-45(2004). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:FOXN4 Research Areas:Epigenetics and Nuclear Signaling;Developmental biology