ELISA SMAD3 (Ab-204) anti-

Quantity :100µL Clone Number: Aliases:DKFZP586N0721 antibody; DKFZp686J10186 antibody; hMAD 3 antibody; hMAD-3 antibody; hSMAD3 antibody; HSPC193 antibody; HST17436 antibody; JV15 2 antibody; JV15-2 antibody; JV152 antibody; LDS1C antibody; LDS3 antibody; MAD (mothers against decapentaplegic Drosophila) homolog 3 antibody; MAD homolog 3 antibody; Mad homolog JV15 2 antibody; Mad protein homolog antibody; MAD; mothers against decapentaplegic homolog 3 antibody; Mad3 antibody; MADH 3 antibody; MADH3 antibody; MGC60396 antibody; Mothers against decapentaplegic homolog 3 antibody; Mothers against DPP homolog 3 antibody; SMA and MAD related protein 3 antibody; SMAD 3 antibody; SMAD antibody; SMAD family member 3 antibody; SMAD; mothers against DPP homolog 3 antibody; Smad3 antibody; SMAD3_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P84022 Immunogen:SyntheQuantityd non-phosphopeptide derived from Smad3 around the phosphorylation site of serine 204 (A-G-S(p)-P-N). Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100 Background:Receptor-regµLated SMAD (R-SMAD) that is an intracellµLar signal transducer and transcriptional modµLator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regµLated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regµLate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modµLating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. RegµLator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regµLates PDPK1 kinase activity by stimµLating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regµLator. Zhang Y., Nature 383:168-172(1996). Riggins G.J., Nat. Genet. 13:347-349(1996). Arai T., Cancer Lett. 122:157-163(1998). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SMAD3 Research Areas:Epigenetics and Nuclear Signaling;Cancer;Metabolism;Signal transduction?Stem cells