ELISA SP100 anti-

Quantity :100µL Clone Number: Aliases:DKFZp686E07254 antibody; FLJ00340 antibody; FLJ34579 antibody; Lysp100b antibody; Nuclear antigen Sp100 antibody; Nuclear autoantigen Sp 100 antibody; Nuclear autoantigen Sp-100 antibody; Nuclear autoantigen Sp100 antibody; Nuclear dot associated Sp100 protein antibody; Nuclear dot-associated Sp100 protein antibody; SP 100 antibody; SP100 antibody; SP100 HMG nuclear autoantigen antibody; SP100 nuclear antigen antibody; SP100_ antibody; Speckled 100 kDa antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P23497 Immunogen:SyntheQuantityd peptide derived from Internal of SP100. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Together with PmL, this tumor suppressor is a major constituent of the PmL bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to Throµgh the regµLation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Throµgh interaction with the MRN complex it may be involved in the regµLation of telomeres lengthening. May also regµLate TP53-mediated transcription and throµgh CASP8AP2, regµLate FAS-mediated apoptosis. Also plays a role in infection by viruses, including cytomegalovirus and Epstein-Barr virus, throµgh mechanisms that may involve chromatin and/or transcriptional regµLation. Dent A.L., Blood 88:1423-1426(1996). Seeler J.-S., Proc. Natl. Acad. Sci. U.S.A. 95:7316-7321(1998). Szostecki C., J. Immunol. 145:4338-4347(1990). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SP100 Research Areas:Epigenetics and Nuclear Signaling;Tags & Cell Markers?Immunology