ELISA UBE2K Antibody, Biotin

Quantity :50µg Clone Number: Aliases:E2 25K antibody; E2(25K) antibody; HIP-2 antibody; Huntingtin interacting protein 2 antibody; Huntingtin-interacting protein 2 antibody; HYPG antibody; LIG antibody; UBC1 antibody; UBE2K antibody; UBE2K_ antibody; Ubiquitin carrier protein antibody; Ubiquitin conjµgating enzyme E2 25 kDa antibody; ubiquitin conjµgating enzyme E2K antibody; ubiquitin conjµgating enzyme E2K (UBC1 homolog, yeast) antibody; Ubiquitin protein ligase antibody; Ubiquitin-conjµgating enzyme E2 K antibody; Ubiquitin-conjµgating enzyme E2(25K) antibody; Ubiquitin-conjµgating enzyme E2-25 kDa antibody; Ubiquitin-conjµgating enzyme E2-25K antibody; Ubiquitin-protein ligase antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P61086 Immunogen:Recombinant Ubiquitin-conjµgating enzyme E2 K protein (2-200AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of \'Lys-48\'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticµLum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages throµgh ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:UBE2K Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Cell biology