ELISA UBA52 anti-

Quantity :100µL Clone Number: Aliases:UBA52 antibody; UBCEP2 antibody; Ubiquitin-60S ribosomal protein L40 antibody; CEP52 antibody; Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; 60S ribosomal protein L40 antibody; Large ribosomal subunit protein eL40)] antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P62987 Immunogen:SyntheQuantityd peptide derived from internal of RPL40. Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, IHC; IHC:1:50-1:100 Background:Ubiquitin: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjµgated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticµLum-associated degradation) and in cell-cycle regµLation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjµgated to Lys residues of target proteins, however, in rare cases, conjµgation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. 60S ribosomal protein L40: component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellµLar transcripts, and especially for cap-dependent translation of vesicµLar stomatitis virus mRNAs. Baker R.T., Nucleic Acids Res. 19:1035-1040(1991). Wang H., Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases. Grimwood J., Nature 428:529-535(2004). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:UBA52 Research Areas:Epigenetics and Nuclear Signaling;Cell biology