ELISA USP8 anti-

Quantity :50µL Clone Number: Aliases:Deubiquitinating enzyme 8 antibody; FLJ34456 antibody; hUBPy antibody; HumORF8 antibody; KIAA0055 antibody; MGC129718 antibody; SPG59 antibody; Ubiquitin carboxyl-terminal hydrolase 8 antibody; Ubiquitin isopeptidase Y antibody; ubiquitin specific peptidase 8 antibody; Ubiquitin thioesterase 8 antibody; Ubiquitin-specific-processing protease 8 antibody; UBP8_ antibody; UBPY antibody; Usp8 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P40818 Immunogen:Recombinant Ubiquitin carboxyl-terminal hydrolase 8 protein (1-270AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200 Background:Hydrolase that can remove conjµgated ubiquitin from proteins and therefore plays an important regµLatory role at the level of protein turnover by preventing degradation. Converts both \\\'Lys-48\\\' an \\\'Lys-63\\\'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimµLation. May regµLate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regµLates the stability of STAM2 and RASGRF1. RegµLates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjµgated ubiquitin from EGFR thus regµLating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis throµgh interaction with the spermatid ESCRT-0 complex and microtubµLes. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:USP8 Research Areas:Epigenetics and Nuclear Signaling; Cell biology; Signal transduction