ELISA USP5 Antibody, HRP

Quantity :50µg Clone Number: Aliases:Deubiquitinating enzyme 5 antibody; Isopeptidase T antibody; ISOT 1 antibody; ISOT antibody; Ubiquitin carboxyl-terminal hydrolase 5 antibody; Ubiquitin isopeptidase T antibody; Ubiquitin specific peptidase 5 (isopeptidase T) antibody; Ubiquitin specific peptidase 5 antibody; Ubiquitin specific processing protease 5 antibody; Ubiquitin specific protease 5 (isopeptidase T) antibody; Ubiquitin specific protease 5 (ubiquitin isopeptidase T) antibody; Ubiquitin thioesterase 5 antibody; Ubiquitin thiolesterase 5 antibody; Ubiquitin-specific-processing protease 5 antibody; UBP5_ antibody; Usp5 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P45974 Immunogen:Recombinant Ubiquitin carboxyl-terminal hydrolase 5 protein (201-500AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Cleaves linear and branched mµLtiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored \'Lys-48\'-linked polyubiquitin disassembly. Binds linear and \'Lys-63\'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumµLation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumµLates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:USP5 Research Areas:Epigenetics and Nuclear Signaling; Cell biology