ELISA TSPAN12 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:TSPAN12 antibody; NET2 antibody; TM4SF12 antibody; UNQ774/PRO1568Tetraspanin-12 antibody; Tspan-12 antibody; Tetraspan NET-2 antibody; Transmembrane 4 superfamily member 12 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O95859 Immunogen:Recombinant Tetraspanin-12 protein (111-224AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:RegµLator of cell surface receptor signal transduction. Plays a central role in retinal vascµLarization by regµLating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 mµLtimerization and subsequent activation of FZD4, leading to promote accumµLation of beta-catenin (CTNNB1) and stimµLate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, sµggesting the existence of a Wnt-independent signaling that also promote accumµLation the beta-catenin (CTNNB1) (By similarity). Acts as a regµLator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TSPAN12 Research Areas:Neuroscience; Cell biology