ELISA TRIM24 anti-

Quantity :50µg Clone Number: Aliases:E3 ubiquitin protein ligase TRIM24 antibody; E3 ubiquitin-protein ligase Trim24 antibody; hTIF1 antibody; PTC6 antibody; RING finger protein 82 antibody; RNF82 antibody; TF1A antibody; TIF1 alpha antibody; TIF1 antibody; TIF1-alpha antibody; TIF1A antibody; TIF1A_ antibody; TIF1ALPHA antibody; Transcription intermediary factor 1-alpha antibody; Transcriptional intermediary factor 1 alpha antibody; Transcriptional intermediary factor 1 antibody; Trim24 antibody; Tripartite motif containing 24 antibody; Tripartite motif-containing protein 24 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O15164 Immunogen:Recombinant Transcription intermediary factor 1-alpha protein (891-1012AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modµLates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at \\\'Lys-4\\\' (H3K4me0) and acetylated at \\\'Lys-23\\\' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regµLation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regµLates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. ModµLates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regµLating retinoic acid-dependent proliferation of hepatocytes (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TRIM24 Research Areas:Epigenetics and Nuclear Signaling; Cell biology