ELISA TRIM13 anti-

Quantity :50µL Clone Number: Aliases:B cell chronic lymphocytic leukemia tumor suppressor Leu5 antibody; B-cell chronic lymphocytic leukemia tumor suppressor Leu5 antibody; CAR antibody; DLEU5 antibody; E3 ubiquitin-protein ligase TRIM13 antibody; HGNC:9976 antibody; LEU5 antibody; Leukemia associated protein 5 antibody; Leukemia-associated protein 5 antibody; Putative tumor suppressor RFP2 antibody; Ret finger protein 2 antibody; RFP2 antibody; RING finger protein 77 antibody; RNF77 antibody; TRI13_ antibody; Trim13 antibody; Tripartite motif protein 13 antibody; Tripartite motif-containing protein 13 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O60858 Immunogen:Recombinant E3 ubiquitin-protein ligase TRIM13 protein (40-310AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200 Background:E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER throµgh a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regµLated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity throµgh MDM2 and AKT1 proteasomal degradation. RegµLates ER stress-induced autophagy, and may act as a tumor suppressor. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TRIM13 Research Areas:Epigenetics and Nuclear Signaling; Cell biology; Signal transduction