ELISA TNFRSF21 anti-

Quantity :50µL Clone Number: Aliases:TNFRSF 21 antibody; BM 018 antibody; BM018 antibody; CD358 antibody; Death receptor 6 antibody; DR 6 antibody; DR6 antibody; MGC31965 antibody; OTTHUMP00000039915 antibody; TNFR related death receptor 6 antibody; TNFRSF21 antibody; TNFRSF21 protein antibody; TNR21_ antibody; Tumor necrosis factor receptor superfamily member 21 antibody; Tumor necrosis factor receptor superfamily member 21 precursor antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O75509 Immunogen:Recombinant Tumor necrosis factor receptor superfamily member 21 protein (371-655AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200 Background:Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regµLates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimµLation of T-cell receptors, in the adaptive immune response and in the regµLation of T-cell differentiation and proliferation. Negatively regµLates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regµLates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimµLation. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TNFRSF21 Research Areas:Cell biology