ELISA TMEM59 anti-

Quantity :50µg Clone Number: Aliases:C1orf8 antibody; HSPC001 antibody; Liver membrane-bound protein antibody; TMEM59 antibody; TMEM59 transmembrane protein 59 antibody; TMM59_ antibody; Transmembrane protein 59 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9BXS4 Immunogen:Recombinant Transmembrane protein 59 protein (59-201AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200 Background:Acts as a regµLator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:27273576, PubMed:23376921). ModµLates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278). Inhibits APP transport to the cell surface and further shedding (PubMed:20427278). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TMEM59 Research Areas:Neuroscience; Tags & Cell Markers; Signal transduction