ELISA TFEB Antibody, Biotin

Quantity :50µg Clone Number: Aliases:Alpha TFEB antibody; AlphaTFEB antibody; bHLHe35 antibody; Class E basic helix-loop-helix protein 35 antibody; T cell transcription factor EB antibody; TCFEB antibody; TFEB antibody; TFEB_ antibody; Transcription factor EB antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P19484 Immunogen:Recombinant Transcription factor EB protein (1-476AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Transcription factor that specifically recognizes and binds E-box sequences (5\'-CANNTG-3\'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5\'-GTCACGTGAC-3\') present in the regµLatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regµLator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobµLin enhancer. Plays a role in the signal transduction processes required for normal vascµLarization of the placenta. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TFEB Research Areas:Epigenetics and Nuclear Signaling; Tags & Cell Markers