ELISA TDP1 anti-

Quantity :50µL Clone Number: Aliases:AI838772 antibody; AW493413 antibody; FLJ11090 antibody; MGC104252 antibody; MGC112732 antibody; RP24-311F12.2 antibody; SCAN1 antibody; TDP1 antibody; TYDP antibody; TYDP1_ antibody; Tyr-DNA phosphodiesterase 1 antibody; Tyrosyl-DNA phosphodiesterase 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9NUW8 Immunogen:Recombinant Tyrosyl-DNA phosphodiesterase 1 protein (1-260AA) Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC, IP; Recommended dilution: WB:1:200-1:2000, IHC:1:20-1:200, IP:1:200-1:2000 Background:DNA repair enzyme that can remove a variety of covalent adducts from DNA throµgh hydrolysis of a 3\\\'-phosphodiester bond, giving rise to DNA with a free 3\\\' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3\\\'-phosphoglycolates on protruding 3\\\' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3\\\'exonuclease activity and can remove a single nucleoside from the 3\\\'end of DNA and RNA molecµLes with 3\\\'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3\\\'phosphate. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TDP1 Research Areas:Epigenetics and Nuclear Signaling