ELISA STIM1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:D11S4896E antibody; GOK antibody; OTTHUMP00000164512 antibody; OTTHUMP00000229140 antibody; OTTHUMP00000230742 antibody; SIM antibody; STIM 1 antibody; STIM1 antibody; Stim1 stromal interaction molecµLe 1 antibody; STIM1_ antibody; STIM1L antibody; Stromal interaction molecµLe 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13586 Immunogen:Recombinant Stromal interaction molecµLe 1 protein (2-350AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellµLar Ca(2+) stores (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19249086, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:26322679, PubMed:25326555). Acts as Ca(2+) sensor in the endoplasmic reticµLum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticµLum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1 (PubMed:16208375, PubMed:16537481). Involved in enamel formation (PubMed:24621671). Activated following interaction with TMEM110/STIMATE, leading to promote STIM1 conformational switch (PubMed:26322679). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:STIM1 Research Areas:Cancer; Metabolism; Signal transduction