ELISA STAMBP anti-

Quantity :50µg Clone Number: Aliases:AMSH antibody; Associated molecµLe with the SH3 domain of STAM antibody; Endosome associated ubiquitin isopeptidase antibody; Endosome-associated ubiquitin isopeptidase antibody; MGC126516 antibody; MGC126518 antibody; MICCAP antibody; STABP_ antibody; STAM binding protein antibody; STAM-binding protein antibody; Stambp antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O95630 Immunogen:Recombinant STAM-binding protein (1-424AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200 Background:Zinc metalloprotease that specifically cleaves \\\'Lys-63\\\'-linked polyubiquitin chains. Does not cleave \\\'Lys-48\\\'-linked polyubiquitin chains.Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regµLation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization Involved in the negative regµLation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:STAMBP Research Areas:Epigenetics and Nuclear Signaling; Cell biology