ELISA SSRP1 anti-

Quantity :50µg Clone Number: Aliases:Chromatin-specific transcription elongation factor 80 kDa subunit antibody; Cisplatin DNA SSRP antibody; Facilitates chromatin remodeling 80 kDa subunit antibody; Facilitates chromatin transcription complex 80 kDa subunit antibody; Facilitates chromatin transcription complex subunit SSRP1 antibody; FACT 80 kDa subunit antibody; FACT complex subunit SSRP1 antibody; FACT80 antibody; FACTp80 antibody; hSSRP1 antibody; Recombination signal sequence recognition protein 1 antibody; Recombination signal sequence recognition protein antibody; SSRP 1 antibody; SSRP1 antibody; SSRP1_ antibody; Structure specific recognition protein 1 antibody; Structure-specific recognition protein 1 antibody; T160 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q08945 Immunogen:Recombinant FACT complex subunit SSRP1 protein (1-242AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IF; Recommended dilution: WB:1:2000-1:5000, IF:1:50-1:200 Background:Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in mµLtiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of \'Ser-392\' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SSRP1 Research Areas:Epigenetics and Nuclear Signaling