ELISA SRPK2 anti-

Quantity :50µL Clone Number: Aliases: serine kinase SRPK2 mRNA, complete cds antibody; Serine kinase SRPK2 antibody; Serine/arginine rich protein specific kinase 2 antibody; Serine/arginine-rich protein-specific kinase 2 antibody; Serine/threonine protein kinase SRPK2 antibody; SFRS protein kinase 2 antibody; SFRSK2 antibody; SR protein specific kinase 2 antibody; SR-protein-specific kinase 2 antibody; SRPK2 antibody; SRPK2_ antibody; SRSF protein kinase 2 C-terminal antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P78362 Immunogen:Recombinant SRSF protein kinase 2 protein (471-688AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200 Background:Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regµLation of splicing. Promotes neuronal apoptosis by up-regµLating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resµLting in cyclin A1 but not cyclin A2 up-regµLation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regµLation of HBV replication throµgh a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SRPK2 Research Areas:Epigenetics and Nuclear Signaling; Cell biology