ELISA SOCS7 Antibody, HRP

Quantity :50µg Clone Number: Aliases:Ash and phospholipase C gamma-binding protein antibody; NAP 4 antibody; NAP 4 Fragment antibody; NAP-4 antibody; NAP4 antibody; Nck antibody; Nck Ash and phospholipase C binding protein antibody; Nck Ash and phospholipase C gamma binding protein antibody; Nck associated protein 4 antibody; Nck-associated protein 4 antibody; NCKAP4 antibody; SH2 domain containing SOCS box protein antibody; SOCS 7 antibody; SOCS-7 antibody; SOCS4 antibody; SOCS6 antibody; Socs7 antibody; SOCS7_ antibody; Suppressor of cytokine signaling 7 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O14512 Immunogen:Recombinant Suppressor of cytokine signaling 7 protein (6-165AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:RegµLates signaling cascades probably throµgh protein ubiquitination and/or sequestration. Functions in insµLin signaling and glucose homeostasis throµgh IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SOCS7 Research Areas:Signal transduction