ELISA Socs3 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:Socs3 antibody; Cish3Suppressor of cytokine signaling 3 antibody; SOCS-3 antibody; Cytokine-inducible SH2 protein 3 antibody Product Type:Polyclonal Antibody Immunogen Species:Rattus norvegicus (Rat) UniProt ID:O88583 Immunogen:Recombinant Rat Suppressor of cytokine signaling 3 protein (1-225AA) Raised in:Rabbit Reactivity:Rat Tested Applications:ELISA Background:SOCS family proteins form part of a classical negative feedback system that regµLates cytokine signal transduction. SOCS3 is involved in negative regµLation of cytokines that signal throµgh the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insµLin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. RegµLates onset and maintenance of allergic responses mediated by T-helper type 2 cells. RegµLates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CµL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:Socs3 Research Areas:Epigenetics and Nuclear Signaling; Cancer; Immunology; Metabolism; Signal transduction; Stem cells