ELISA SOCS1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:CISH 1 antibody; CISH1 antibody; Cytokine inducible SH2 protein 1 antibody; JAB antibody; JAK binding protein antibody; JAK-binding protein antibody; Janus kinase binding protein antibody; SOCS 1 antibody; SOCS-1 antibody; Socs1 antibody; SOCS1_ antibody; SSI 1 antibody; SSI-1 antibody; SSI1 antibody; STAT induced STAT inhibitor 1 antibody; STAT-induced STAT inhibitor 1 antibody; Suppressor of cytokine signaling 1 antibody; Supressor of cytokine signalling 1 antibody; TEC interacting protein 3 antibody; Tec-interacting protein 3 antibody; TIP 3 antibody; TIP-3 antibody; TIP3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O15524 Immunogen:Recombinant Suppressor of cytokine signaling 1 protein (1-211AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:SOCS family proteins form part of a classical negative feedback system that regµLates cytokine signal transduction. SOCS1 is involved in negative regµLation of cytokines that signal throµgh the JAK/STAT3 pathway. Throµgh binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regµLator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). RegµLates interferon-gamma mediated sensory neuron survival By similarity. Probable substrate recognition component of an ECS (Elongin BC-CµL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regµLator in IGF1R signaling pathway. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SOCS1 Research Areas:Epigenetics and Nuclear Signaling; Immunology; Signal transduction