ELISA SNAI2 anti-

Quantity :50µg Clone Number: Aliases:MGC10182 antibody; Neural crest transcription factor Slµg antibody; Protein snail homolog 2 antibody; Slµg (chicken homolog) zinc finger protein antibody; Slµg homolog zinc finger protein antibody; Slµg zinc finger protein antibody; SLµgH antibody; SLµgH 1 antibody; SLµgH1 antibody; SNAI 2 antibody; Snai2 antibody; SNAI2_ antibody; Snail 2 antibody; Snail homolog 2 antibody; Snail2 antibody; WS 2D antibody; WS2D antibody; Zinc finger protein SLµg antibody; Zinc finger protein SNAI2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O43623 Immunogen:Recombinant Zinc finger protein SNAI2 protein (12-124AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200 Background:Transcriptional repressor that modµLates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regµLation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regµLator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SNAI2 Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Cancer; Developmental biology; Stem cells