ELISA SEM1 Antibody, HRP

Quantity :50µg Clone Number: Aliases:SEM1 antibody; C7orf76 antibody; DSS1 antibody; SHFDG1 antibody; SHFM1 antibody; 26S proteasome complex subunit SEM1 antibody; 26S proteasome complex subunit DSS1 antibody; Deleted in split hand/split foot protein 1 antibody; Split hand/foot deleted protein 1 antibody; Split hand/foot malformation type 1 protein antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P60896 Immunogen:Recombinant 26S proteasome complex subunit SEM1 protein (1-70AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Component of the 26S proteasome, a mµLtiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which coµLd impair cellµLar functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellµLar processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumµLation increases in SEM1-depleted cells. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SEM1 Research Areas:Cell biology