ELISA SAMHD1 Antibody, HRP

Quantity :50µL Clone Number: Aliases:CHBL2 antibody; DCIP antibody; Dendritic cell derived IFNG induced protein antibody; Dendritic cell-derived IFNG-induced protein antibody; Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 antibody; dNTPase antibody; HD domain containing 1 antibody; HDDC1 antibody; Mg11 antibody; Monocyte protein 5 antibody; MOP 5 antibody; MOP-5 antibody; MOP5 antibody; OTTHUMP00000030889 antibody; SAM domain and HD domain 1 antibody; SAM domain and HD domain containing protein 1 antibody; SAM domain and HD domain-containing protein 1 antibody; SAMH1_ antibody; Samhd1 antibody; SBBI88 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9Y3Z3 Immunogen:Recombinant Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 protein (1-314AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Host restriction nuclease involved in defense response to virus. Has dNTPase activity and reduces cellµLar dNTP levels to levels too low for retroviral reverse transcription to occur. Blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May play a role in mediating proinflammatory responses to TNF-alpha signaling (PubMed:18546154, PubMed:19525956, PubMed:22056990, PubMed:24336198, PubMed:28229507). Has ribonuclease activity, acting on single-stranded RNA. This activity is essential for H1V-1 restriction (PubMed:25038827). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Antigen Affinity purified & Affinity purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SAMHD1 Research Areas:Signal Transduction