ELISA S100a8 Antibody, FITC

Quantity :50µg Clone Number: Aliases:S100a8 antibody; Caga antibody; Mrp8 antibody; Protein S100-A8 antibody; CalgranµLin-A antibody; Chemotactic cytokine CP-10 antibody; Leukocyte L1 complex light chain antibody; Migration inhibitory factor-related protein 8 antibody; MRP-8 antibody; p8 antibody; Pro-inflammatory S100 cytokine antibody; S100 calcium-binding protein A8 antibody Product Type:Polyclonal Antibody Immunogen Species:Mus muscµLus (Mouse) UniProt ID:P27005 Immunogen:Recombinant Mouse Protein S100-A8 protein (2-89AA) Raised in:Rabbit Reactivity:Mouse Tested Applications: Background:S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regµLation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellµLar functions. The intracellµLar functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modµLation of the tubµLin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellµLar functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regµLation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecµLar pattern (DAMP) molecµLe and stimµLates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resµLting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn2+ which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs throµgh the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regµLate neutrophil number and apoptosis by an anti-apoptotic effect; regµLates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:S100a8 Research Areas:Neuroscience; Cancer