ELISA RASGRP1 Antibody, FITC

Quantity :50µg Clone Number: Aliases:RASGRP1 antibody; RASGRPRAS guanyl-releasing protein 1 antibody; Calcium and DAG-regµLated guanine nucleotide exchange factor II antibody; CalDAG-GEFII antibody; Ras guanyl-releasing protein antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O95267 Immunogen:Recombinant RAS guanyl-releasing protein 1 protein (594-716AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Functions as a calcium- and diacylglycerol (DAG)-regµLated nucleotide exchange factor specifically activating Ras throµgh the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849). RegµLates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). RegµLates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranµLation and cytokine secretion, regµLating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types (PubMed:12845332). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RASGRP1 Research Areas:Neuroscience; Cancer; Signal transduction