ELISA PAK3 Antibody, FITC

Quantity :50µg Clone Number: Aliases:PAK3 antibody; OPHN3 antibody; Serine/threonine-protein kinase PAK 3 antibody; EC 2.7.11.1 antibody; Beta-PAK antibody; Oligophrenin-3 antibody; p21-activated kinase 3 antibody; PAK-3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O75914 Immunogen:Recombinant Serine/threonine-protein kinase PAK 3 protein (70-190AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regµLation, cell migration, or cell cycle regµLation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 resµLts in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regµLator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modµLate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PAK3 Research Areas:Neuroscience; Signal transduction