ELISA PAFAH1B1 anti-

Quantity :50µg Clone Number: Aliases:LIS 1 antibody; LIS 2 antibody; LIS-1 antibody; LIS1 antibody; LIS1_ antibody; LIS2 antibody; Lissencephaly 1 protein antibody; Lissencephaly-1 protein antibody; MDCR antibody; MDS antibody; PAF acetylhydrolase 45 kDa subunit antibody; PAF AH 45 kDa subunit antibody; PAF AH alpha antibody; PAF-AH 45 kDa subunit antibody; PAF-AH alpha antibody; PAFAH alpha antibody; PAFAH antibody; PAFAH1B1 antibody; PAFAHA antibody; Platelet activating factor acetylhydrolase 1b regµLatory subunit 1 antibody; Platelet activating factor acetylhydrolase isoform Ib alpha subunit antibody; Platelet-activating factor acetylhydrolase IB subunit alpha antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P43034 Immunogen:Recombinant Platelet-activating factor acetylhydrolase IB subunit alpha protein (40-155AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IF; Recommended dilution: IF:1:50-1:200 Background:Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regµLates the activity of the minus-end directed microtubµLe motor protein dynein. May enhance dynein-mediated microtubµLe sliding by targeting dynein to the microtubµLe plus end. Required for several dynein- and microtubµLe-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubµLe fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricµLar/subventricµLar zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubµLes. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PAFAH1B1 Research Areas:Neuroscience; Signal transduction