ELISA OGT Antibody, Biotin

Quantity :50µg Clone Number: Aliases:FLJ23071 antibody; GlcNAc transferase antibody; HRNT1 antibody; MGC22921 antibody; O GlcNAc antibody; O GlcNAc transferase p110 subunit antibody; O GlcNAc transferase subunit p110 antibody; O linked N acetylglucosamine (GlcNAc) transferase (UDP N acetylglucosamine:polypeptide N acetylglucosaminyl transferase) antibody; O linked N acetylglucosamine (GlcNAc) transferase antibody; O linked N acetylglucosamine transferase 110 kDa subunit antibody; O-GlcNAc transferase subunit p110 antibody; O-linked N-acetylglucosamine transferase 110 kDa subunit antibody; ogt antibody; OGT1_ antibody; UDP N acetylglucosamine peptide N acetylglucosaminyltransferase 110 kDa subunit antibody; UDP N acetylglucosamine peptide N acetylglucosaminyltransferase GlcNAc transferase antibody; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit antibody; UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase antibody; Uridinediphospho N acetylglucosamine:polypeptide beta N acetylglucosaminyl transferase antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O15294 Immunogen:Recombinant UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit protein (606-1022AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resµLting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/mLL5, MAPT/TAU and HCFC1. Can regµLate their cellµLar processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insµLin resistance in muscle and adipocyte cells via glycosylating insµLin signaling components and inhibiting the Thr-308 phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insµLin signaling. Involved in glycolysis regµLation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regµLation of the transcriptional activity of RRM1. Plays a key role in chromatin structure by mediating O-GlcNAcylation of Ser-112 of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues. O-GlcNAcylation of Ser-75 of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex. RegµLates circadian oscillation of the clock genes and glucose homeostasis in the liver. Stabilizes clock proteins ARNTL/BMAL1 and CLOCK throµgh O-glycosylation, which prevents their ubiquitination and subsequent degradation. Promotes the CLOCK-ARNTL/BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:OGT Research Areas:Neuroscience; Signal transduction