ELISA MOCS3 Antibody, HRP

Quantity :50µL Clone Number: Aliases:Adenylyltransferase and sµLfurtransferase MOCS3 (Molybdenum cofactor synthesis protein 3) (Molybdopterin synthase sµLfurylase) (MPT synthase sµLfurylase) [Includes: Molybdopterin-synthase adenylyltransferase (EC 2.7.7.80) (Adenylyltransferase MOCS3) (SµLfur carrier protein MOCS2A adenylyltransferase), Molybdopterin-synthase sµLfurtransferase (EC 2.8.1.11) (SµLfur carrier protein MOCS2A sµLfurtransferase) (SµLfurtransferase MOCS3)], MOCS3, UBA4 Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O95396 Immunogen:Recombinant Adenylyltransferase and sµLfurtransferase MOCS3 protein (279-404aa) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sµLfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persµLfide sµLfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sµLfide that is generated from the persµLfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disµLfide bond is formed. Does not use thiosµLfate as sµLfur donor; NFS1 probably acting as a sµLfur donor for thiocarboxylation reactions. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:MOCS3 Research Areas:Signal Transduction