ELISA MAP3K8 Antibody, HRP

Quantity :50µg Clone Number: Aliases:AURA2 antibody; c COT antibody; Cancer Osaka thyroid oncogene antibody; CCOT antibody; COT antibody; COT proto oncogene serine/threonine protein kinase antibody; EST antibody; ESTF antibody; Ewing sarcoma transformant antibody; FLJ10486 antibody; M3K8_ antibody; MAP3K 8 antibody; MAP3K8 antibody; MEKK8 antibody; Mitogen activated protein kinase kinase kinase 8 antibody; Mitogen-activated protein kinase kinase kinase 8 antibody; Proto oncogene cCot antibody; Proto-oncogene c-Cot antibody; Serine/threonine protein kinase cot antibody; Serine/threonine-protein kinase cot antibody; TPL 2 antibody; TPL-2 antibody; TPL2 antibody; Tumor progression locus 2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P41279 Immunogen:Recombinant Mitogen-activated protein kinase kinase kinase 8 protein (1-300AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regµLation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection throµgh negative regµLation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regµLation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regµLation of immunoglobµLin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insµLin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, althoµgh it is much weaker than that of the activated oncogenic variant. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:MAP3K8 Research Areas:Cancer; Signal transduction