ELISA KPNA6 anti-

Quantity :50µL Clone Number: Aliases:FLJ11249 antibody; IMA7_ antibody; Importin alpha 7 subunit antibody; Importin alpha S2 antibody; Importin subunit alpha 7 antibody; Importin subunit alpha-7 antibody; IPOA 7 antibody; IPOA7 antibody; Karyopherin alpha 6 antibody; Karyopherin alpha 6 (importin alpha 7) antibody; Karyopherin subunit alpha 6 antibody; Karyopherin subunit alpha-6 antibody; KPNA 6 antibody; KPNA 7 antibody; Kpna6 antibody; KPNA7 antibody; MGC17918 antibody; OTTHUMP00000004532 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O60684 Immunogen:Recombinant Importin subunit alpha-7 protein (277-536AA) Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200 Background:Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 throµgh binding to nucleoporin FxFG repeats and the complex is subsequently translocated throµgh the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thoµght to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:KPNA6 Research Areas:Signal transduction