ELISA ERLIN2 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:C8orf2 antibody; Chromosome 8 open reading frame 2 antibody; Endoplasmic reticµLum lipid raft associated protein 2 antibody; Endoplasmic reticµLum lipid raft-associated protein 2 antibody; ER lipid raft associated 2 antibody; ERLIN 2 antibody; Erlin-2 antibody; ERLIN2 antibody; ERLN2_ antibody; HGNC:1356 antibody; MGC87072 antibody; NET32 antibody; SPFH 2 antibody; SPFH domain containing protein 2 antibody; SPFH domain family member 2 antibody; SPFH domain-containing protein 2 antibody; SPFH2 antibody; SPG18 antibody; Stomatin prohibitin flotillin HflC/K domain containing protein 2 antibody; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O94905 Immunogen:Recombinant Erlin-2 protein (25-206AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticµLum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). Involved in regµLation of cellµLar cholesterol homeostasis by regµLation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed:24217618). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ERLIN2 Research Areas:Neuroscience; Signal transduction