ELISA DPYD anti-

Quantity :100µL Clone Number: Aliases:DHP antibody; DHPDHase antibody; Dihydropyrimidine dehydrogenase [NADP(+)] antibody; Dihydropyrimidine dehydrogenase [NADP+] antibody; Dihydropyrimidine dehydrogenase antibody; Dihydrothymine dehydrogenase antibody; Dihydrouracil dehydrogenase antibody; DPD antibody; DPYD antibody; DPYD_ antibody; MGC132008 antibody; MGC70799 antibody; OTTHUMP00000058954 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q12882 Immunogen:Recombinant protein of DPYD Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC; WB:1:500-1:2000, IHC:1:50-1:200 Background:Dihydropyrimidine dehydrogenase (DPD, DPYD) catalyzes the initial and rate-limiting step in uracil and thymidine catabolism as well as catabolism of the chemotherapeutic drµg 5-fluorouracil (5-FU) and its derivatives. DPYD deficiency, which resµLts from mutations in the DPYD gene, causes errors in pyrimidine metabolism and potentially life-threatening side effects in cancer patients treated with 5-FU (reviewed in 1). As a resµLt, ongoing work examines whether or how DPYD gene variation and protein expression can be used to predict 5-FU toxicity. Several genes that impart resistance to 5-FU were recently identified in hepatocellµLar carcinoma (HCC). AEG-1, which is highly expressed in HCC, increases the expression of DPYD. DPYD is expressed more highly in HCC than in normal liver, and this is thoµght to be one mechanism of 5-FU resistance. Clonality:Polyclonal Isotype:IgG Purification Method:Affinity purification Conjµgate:Non-conjµgated Buffer:Store at -20°C or -80°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:DPYD Research Areas:Cancer;Metabolism;Signal transduction