ELISA Ctcfl anti-

Quantity :50µg Clone Number: Aliases:Ctcfl antibody; Boris antibody; Transcriptional repressor CTCFL antibody; Brother of the regµLator of imprinted sites antibody; CCCTC-binding factor antibody; CTCF paralog antibody; CTCF-like protein antibody Product Type:Polyclonal Antibody Immunogen Species:Mus muscµLus (Mouse) UniProt ID:A2APF3 Immunogen:Recombinant Mouse Transcriptional repressor CTCFL protein (1-636AA) Raised in:Rabbit Reactivity:Mouse, Tested Applications:ELISA, WB; Recommended dilution: WB:1:500-1:2000 Background:Testis-specific DNA binding protein responsible for insµLator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germLine, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 \\\'Arg-3\\\' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:Ctcfl Research Areas:Epigenetics and Nuclear Signaling; Cancer