ELISA TPMT anti-

Quantity :50µg Clone Number: Aliases:HGNC:12014 antibody; S adenosyl L methionine thiopurine S methyltransferase antibody; Thiopurine methyltransferase antibody; Thiopurine S methyltransferase antibody; Thiopurine S-methyltransferase antibody; TPMT antibody; TPMT_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P51580 Immunogen:Recombinant Thiopurine S-methyltransferase protein (4-244AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC, IP; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000 Background:TPMT is an enzyme that metabolizes thiopurine drµgs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drµgs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drµgs within individuals. A pseudogene for this locus is located on chromosome 18q. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TPMT Research Areas:Metabolism; Signal transduction