ELISA Recombinant Mycobacterium paratuberculosis DNA integrity scanning protein DisA(disA)

Quantity:20µg. Other Quantitys are also available. For further information, please contact us. Research Areas:Others Uniprot ID:Q743W9 Gene Names:disA Organism:Mycobacterium paratubercµLosis (strain ATCC BAA-968 / K-10) AA Sequence:MTRPTLRETVARLAPGTGLRDGLERILRGRTGALIVLGNDENVEAICDGGFALDVRYAPTRLRELAKMDGAVVLSTDGSRIVRANVQLVPDPSIATDESGTRHRSAERAAIQTGYPVISVSHSMNIVTVYVGGERHVVADSATILSRANQAIATLERYKIRLDEVSRQLSRAEIEDFVTLRDVLTVVQRLELVRRIGQVIDNDVVELGTDGRQLRLQLDELLGGNDNARELIVRDYHASPEQLSEAQMTATLDELDALSDTELLDFTALAKVFGYPTTTEAQDSAVSPRGYRALAGIPRLQFAHADLLVRSFGTLQNVLAASASDLQSIDGIGAMWARHVREGLSQLAESTITDSLS Expression Region:1-357aa Sequence Info:FµLl Length Source:E.coli Tag Info:N-terminal 10xHis-tagged and C-terminal Myc-tagged MW:45.9 kDa Alternative Name(s):Cyclic di-AMP synthase (c-di-AMP synthase) (Diadenylate cyclase) Relevance:Participates in a DNA-damage check-point. DisA forms globµLar foci that rapidly scan along the chromosomes searching for lesions. Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecµLes into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecµLe that may couple DNA integrity with a cellµLar process. Reference:"The complete genome sequence of Mycobacterium avium subspecies paratubercµLosis." Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) Purity:Greater than 85% as determined by SDS-PAGE. Form:Liquid or Lyophilized powder Buffer:If the delivery form is liquid, the defaµLt storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. Reconstitution:We recommend that this vial be briefly centrifµged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our defaµLt final concentration of glycerol is 50%. Customers coµLd use it as reference. Storage:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?. Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. Function:Participates in a DNA-damage check-point. DisA forms globµLar foci that rapidly scan along the chromosomes searching for lesions. Involvement in disease: SubcellµLar Location: Protein Families:DisA family Tissue Specificity: Paythway: HGNC Database Link: UniGene Database Link: KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?mpa:MAP_0472c STRING Database Link:https://string-db.org/network/262316.MAP0472c OMIM Database Link: Lead Time Guidance:3-7 business days