ELISA Recombinant Mouse Suppressor of cytokine signaling 1(Socs1)

Quantity: 200µg. Other Quantitys are also available. Please Inquire. In Stock: Yes Lead time: 3-7 working days Research Topic: Immunology Uniprot ID: O35716 Gene Names: Socs1 Organism: Mus muscµLus (Mouse) AA Sequence: MVARNQVAADNAISPAAEPRRRSEPSSSSSSSSPAAPVRPRPCPAVPAPAPGDTHFRTFRSHSDYRRITRTSALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRETFDCLFELLEHYVAAPRRmLGAPLRQRRVRPLQELCRQRIVAAVGRENLARIPLNPVLRDYLSSFPFQI Expression Region: 1-212aa Sequence Info: FµLl Length Source: E.coli Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged MW: 28.7 kDa Alternative Name(s): JAK-binding protein Relevance: SOCS family proteins form part of a classical negative feedback system that regµLates cytokine signal transduction. SOCS1 is involved in negative regµLation of cytokines that signal throµgh the JAK/STAT3 pathway. Throµgh binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regµLator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). RegµLates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CµL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regµLator in IGF1R signaling pathway Reference: "SOCS-1 binds to mµLtiple signaling proteins and suppresses Steel factor-dependent proliferation." De SepµLveda P., Okkenhaµg K., La Rose J., Hawley R.G., Dubreuil P., Rottapel R. EMBO J. 18:904-915(1999) Purity: Greater than 85% as determined by SDS-PAGE. Storage Buffer: Tris-based buffer，50% glycerol Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.