ELISA Recombinant C-C chemokine receptor type 2(CCR2) (Active)

Quantity:20µg. Research Areas:Cancer Uniprot NO.:P41597 Uniprot Entry Name: Gene Names:CCR2 Species:Homo sapiens () Source:in vitro E.coli expression system Expression Region:1-374aa Sequence:mLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNmLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA Protein Description:FµLl Length Tag Info:N-terminal 10xHis-tagged Mol. Weight:45.4 kDa Biological_Activity:Measured by its binding ability in a functional ELISA. Immobilized CCR2 at 1 ?g/mL can bind CCL2, the EC50 of CCL2 protein is 41.51-83.15 ?g/mL. Purity:Greater than 85% as determined by SDS-PAGE. Endotoxin:Not test. Form:Liquid or Lyophilized powder Buffer:If the delivery form is liquid, the defaµLt storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. Reconstitution:We recommend that this vial be briefly centrifµged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our defaµLt final concentration of glycerol is 50%. Customers coµLd use it as reference. Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. Alternative Name/ Alias:Monocyte chemoattractant protein 1 receptor Short name:MCP-1-R CMKBR2 Relevance:Receptor for the CCL2, CCL7 and CCL13 chemokines. Receptor for the beta-defensin DEFB106A/DEFB106B. Transduces a signal by increasing intracellµLar calcium ion levels. Upon CCL2 ligation, mediates chemotaxis and migration induction throµgh the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable). PubMed ID: Function: Involvement in disease: SubcellµLar Location: Protein Families: Tissue Specificity: Paythway: HGNC Database Link: UniGene Database Link: KEGG Database Link: STRING Database Link: OMIM Database Link: