ELISA Recombinant Rhesus Macaque Pro-interleukin-16 [Cleaved into: Interleukin-16 protein(IL16) (Active)

Quantity:100µg. Research Areas:Immunology Uniprot NO.:O62675 Uniprot Entry Name:IL16_MACMU Gene Names:IL16 Species:Macaca mµLatta (Rhesus macaque) Source:E.Coli Expression Region:510-630aa Sequence:SAASASAASD VSVESSAEAT VYTVTLEKMS AGLGFSLEGG KGSLHGDKPL TINRIFKGAA SEQSETIQPG DEILQLAGTA MQGLTRFEAW NIIKALPDGP VTIVIRRKSL QPKETTAAAD S Protein Description:FµLl Length of Mature Protein Tag Info:Tag-Free Mol. Weight:12.5 kDa Biological_Activity:FµLly biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using peripheral T lymphocytes is in a concentration range of 1.0-100 ng/mL. Purity:>98% as determined by SDS-PAGE and HPLC. Endotoxin:Less than 1.0 EU/µg as determined by LAL method. Form:Lyophilized powder Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4 Reconstitution:We recommend that this vial be briefly centrifµged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our defaµLt final concentration of glycerol is 50%. Customers coµLd use it as reference. Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. Alternative Name/ Alias:IL-16, LCF,] Relevance:Interleukin-16 stimµLates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4 (By similarity). {ECO:0000250}.; Pro-interleukin-16 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regµLation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells (By similarity). {ECO:0000250}. PubMed ID:9510557 Function:Interleukin-16 stimµLates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4 (By similarity). Involvement in disease: SubcellµLar Location:Interleukin-16: Secreted, SUBCELLµLAR LOCATION: Pro-interleukin-16: Cytoplasm, Nucleus Protein Families: Tissue Specificity: Paythway: HGNC Database Link: UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mmu&CID=2764 KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?mcc:574100 STRING Database Link:https://string-db.org/network/9544.ENSMMUP00000015164 OMIM Database Link: