ELISA Recombinant Interleukin-20 protein(IL20) (Active)

Quantity:100µg. Research Areas:Immunology Uniprot NO.:Q9NYY1 Uniprot Entry Name:IL20_ Gene Names:IL20,ZCYTO10,UNQ852/PRO1801 Species:Homo sapiens () Source:E.Coli Expression Region:25-176aa Sequence:M+LKTLNLGSC VIATNLQEIR NGFSEIRGSV QAKDGNIDIR ILRRTESLQD TKPANRCCLL RHLLRLYLDR VFKNYQTPDH YTLRKISSLA NSFLTIKKDL RLCHAHMTCH CGEEAMKKYS QILSHFEKLE PQAAVVKALG ELDILLQWME ETE Protein Description:FµLl Length of Mature Protein Tag Info:Tag-Free Mol. Weight:17.6 kDa Biological_Activity:FµLly biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using IL-20R? and IL-20R? co-transfected murine BaF3 pro-B cells is less than 0.5 ng/mL, corresponding to a specific activity of ? 2.0 ×106 IU/mg. Purity:>95% as determined by SDS-PAGE and HPLC. Endotoxin:Less than 1.0 EU/µg as determined by LAL method. Form:Lyophilized powder Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.2, with trehalose Reconstitution:We recommend that this vial be briefly centrifµged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our defaµLt final concentration of glycerol is 50%. Customers coµLd use it as reference. Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. Alternative Name/ Alias:IL-20, Relevance:Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act throµgh STAT3. {ECO:0000269|PubMed:16511554}. PubMed ID:11163236; 16511554; 12975309; 16710414; 15489334; 15340161; 16908179; 16709143; 22802649 Function:Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act throµgh STAT3. Involvement in disease: SubcellµLar Location:Secreted Protein Families:IL-10 family Tissue Specificity:Expressed in most tissues and five major cell types: epithelial cells (primarily skin, buccal mucosa, tongue, nasal mucosa, lung, ureter, breast, prostate, fallopian tube, and adrenal gland), myoepithelial cells (mainly prostate), endothelial cells (mainly in small vessels or capillaries), macrophages, and skeletal muscle. Isoform 2 was detected in the lung tissue only. Paythway:Jak-STATsignalingpathway HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:6002 UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=272373 KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:50604 STRING Database Link:https://string-db.org/network/9606.ENSP00000356063 OMIM Database Link:https://www.omim.org/entry/605619605619605619