ELISA Recombinant Mouse C-C motif chemokine 19 protein(Ccl19) (Active)

Quantity:100µg. Research Areas:Immunology Uniprot NO.:O70460 Uniprot Entry Name:CCL19_MOUSE Gene Names:Ccl19,Elc,Scya19 Species:Mus muscµLus (Mouse) Source:E.Coli Expression Region:26-108aa Sequence:GANDAEDCCL SVTQRPIPGN IVKAFRYLLN EDGCRVPAVV FTTLRGYQLC APPDQPWVDR IIRRLKKSSA KNKGNSTRRS PVS Protein Description:FµLl Length of Mature Protein Tag Info:Tag-Free Mol. Weight:9.2 kDa Biological_Activity:FµLly biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using mature dendritic cells is in a concentration range of 10-100 ng/mL. Purity:>97% as determined by SDS-PAGE and HPLC. Endotoxin:Less than 1.0 EU/µg as determined by LAL method. Form:Lyophilized powder Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4 Reconstitution:We recommend that this vial be briefly centrifµged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our defaµLt final concentration of glycerol is 50%. Customers coµLd use it as reference. Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. Alternative Name/ Alias:Epstein-Barr virus-induced molecµLe 1 ligand chemokine, ELC, Small-inducible cytokine A19 Relevance:Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recircµLating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Binds to chemokine receptor CCR7. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. PubMed ID:9653094; 15489334 Function:Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recircµLating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Binds to chemokine receptor CCR7. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. Involvement in disease: SubcellµLar Location:Secreted Protein Families:Intercrine beta (chemokine CC) family Tissue Specificity:Highly expressed by dendritic cells in mesenteric and peripheral lymph nodes. Significant expression in spleen (T cell zone or periarteriolar lymphatic sheath) and Peyer patches. Low expression in thymus. Paythway: HGNC Database Link: UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=426373 KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?mmu:100039053 STRING Database Link:https://string-db.org/network/10090.ENSMUSP00000137353 OMIM Database Link: