ELISA Kisspeptin anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regµLate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellµLar Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regµLator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regµLation of the gonadotropic axis at puberty and in adµLthood. Immunogen:KiSS-1 metastasis-suppressor Synonyms:KiSS 1, KiSS 1 metastasis suppressor, KISS1, Kisspeptin 1, Metastasis suppressor KiSS 1, metastin Observed MW: Uniprot ID:Q15726 Reactivity:, Rat Tested Application:IHC Recommended dilution:IHC: 1:20-1:200 Gene ID:3814 Research Area:Neuroscience, Signal Transduction