ELISA SHARPIN anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Component of the LUBAC complex which conjµgates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regµLation of inflammation. LUBAC conjµgates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex(TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjµgate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otµLin, the LUBAC complex regµLates the canonical Wnt signaling during angiogenesis. Immunogen:SHANK-associated RH domain interactor Synonyms:hSIPL1, SHARPIN, SIPL1 Observed MW:40 kDa Uniprot ID:Q9H0F6 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 Gene ID:81858 Research Area:Neuroscience