ELISA USP15 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Hydrolase that removes conjµgated ubiquitin from target proteins and regµLates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regµLator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs(SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes(PubMed:21947082). According to another reports, regµLates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal(PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regµLate gene expression and/or DNA repair throµgh the deubiquitination of histone H2B(PubMed:24526689). Acts as an associated component of COP9 signalosome complex(CSN) and regµLates different pathways via this association: regµLates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway. Immunogen:ubiquitin specific peptidase 15 Synonyms:Deubiquitinating enzyme 15, KIAA0529, Ubiquitin thiolesterase 15, Unph 2, UNPH4, USP15 Observed MW:112 kDa Uniprot ID:Q9Y4E8 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IP Recommended dilution:WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:50-1:500 Gene ID:9958 Research Area:Epigenetics, Metabolism