ELISA USP11 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Protease that can remove conjµgated ubiquitin from target proteins and polyubiquitin chains(PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799). Inhibits the degradation of target proteins by the proteasome(PubMed:12084015). Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains(in vitro)(PubMed:24724799). Plays a role in the regµLation of pathways leading to NF-kappa-B activation(PubMed:17897950, PubMed:19874889). Plays a role in the regµLation of DNA repair after double-stranded DNA breaks(PubMed:15314155, PubMed:20233726). Immunogen:ubiquitin specific peptidase 11 Synonyms:Deubiquitinating enzyme 11, Ubiquitin thiolesterase 11, UHX1, USP11 Observed MW:110 kDa Uniprot ID:P51784 Reactivity: Tested Application:ELISA, WB, IHC, IP, IF Recommended dilution:WB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:1000-1:10000; IF: 1:20-1:200 Gene ID:8237 Research Area:Epigenetics, Metabolism