ELISA Ubiquilin 1 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:UBQLN1, also known as DSK2 or Ubiquilin 1, is an ubiquitin-like proteinis contains a?N-terminal?ubiquitin-like?domain?and a C-terminal ubiquitin-associated domain.?They physically associate with both proteasomes and ubiquitin ligases, and thus are thoµght to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation.Ubiquilin has also been shown to modµLate accumµLation of presenilin proteins, and is found in lesions associated with?Alzheimer's?and?Parkinson's?disease. Two transcript variants encoding different isoforms have been found for this gene. Higher levels of ubiquilin-1 in the brain decreased malformation of the APP molecµLe which plays a key role in triggering Alzheimers disease.Conversely, lower levels of ubiquilin-1 in the brain were associated with increased malformation of APP?(PMID: 21852239). This antibody detects 70kD band of UBQLN1. Immunogen:ubiquilin 1 Synonyms:DA41, DSK2, FLJ90054, hPLIC 1, PLIC 1, PLIC1, ubiquilin 1, UBQLN1, XDRP1 Observed MW:71 kDa Uniprot ID:Q9UMX0 Reactivity:, Rat Tested Application:ELISA, IHC, WB, IF Recommended dilution:WB: 1:200-1:1000; IF: 1:10-1:100; IHC: 1:20-1:200 Gene ID: Research Area:Metabolism