ELISA TSPAN12 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:RegµLator of cell surface receptor signal transduction. Plays a central role in retinal vascµLarization by regµLating norrin(NDP) signal transduction. Acts in concert with norrin(NDP) to promote FZD4 mµLtimerization and subsequent activation of FZD4, leading to promote accumµLation of beta-catenin(CTNNB1) and stimµLate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin(NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, sµggesting the existence of a Wnt-independent signaling that also promote accumµLation the beta-catenin(CTNNB1)(By similarity). Acts as a regµLator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein(APP). Activates MMP14/MT1-MMP-dependent cleavage activity. Immunogen:tetraspanin 12 Synonyms:NET 2, NET2, Tetraspan NET 2, tetraspanin 12, TM4SF12, Tspan 12, TSPAN12 Observed MW:28 kDa Uniprot ID:O95859 Reactivity:, Mouse, Rat Tested Application:ELISA, WB Recommended dilution:WB: 1:200-1:2000 Gene ID:23554 Research Area:CardiovascµLar, Signal Transduction