ELISA TRIM33 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimµLates erythroid differentiation of hematopoietic stem/progenitor(By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade(Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resµLting in inhibition of TGF-beta/BMP signaling cascade). Immunogen:tripartite motif-containing 33 Synonyms:Ectodermin homolog, FLJ32925, KIAA1113, Protein Rfg7, PTC7, RET fused gene 7 protein, RFG7, TF1G, TIF1 gamma, TIF1G, TIF1GAMMA, TIFGAMMA, TRIM33, tripartite motif containing 33 Observed MW:140-150 kDa Uniprot ID:Q9UPN9 Reactivity: Tested Application:ELISA, WB Recommended dilution:WB: 1:200-1:2000 Gene ID:51592 Research Area:Metabolism